Chicago has three museums in Forbes list of the top 25 museums in the U.S. ranked by the number of visitors

Smithsonian Institution’s National Museum of Natural History, Washington, D.C. - 5.8 million
Smithsonian Institution's National Air and Space Museum, Washington D.C. - 5 million
National Gallery of Art, Washington, D.C. - 4.69 million
Metropolitan Museum, NY - 4.5 million
American Museum of Natural History, NY - 4 million
National Museum of American History - 2.4 million
Museum of Modern Art, New York - 2.22 Million
Field Museum, Chicago, IL - 2.1 million
Museum of Science, Boston - 2.01 million
Ellis Island Immigration Museum, New York - 1.67 million
Smithsonian's National Museum of the American Indian - 1.6 million (tie)
De Young Museum, San Francisco - 1.6 million (tie)
United States Holocaust Memorial Museum, Washington, D.C. - 1.5 million
California Science Center, Los Angeles, CA - 1.4 million
Chicago Museum of Science and Industry - 1.38 million
The J. Paul Getty Museum at the Getty Center, Los Angeles - 1.3 million (tie)
The Art Institute of Chicago - 1.3 million (tie)
Indianapolis Children's Museum - 1.2 million
Museum of Fine Arts, Houston - 1.12 million
Franklin Institute Science Museum, Philadelphia - 1.12 million
The Science Museum of Minnesota - 1.11 million
Museum of Fine Arts, Boston - 1.1 million
Pacific Science Center, Seattle, WA - 1.02 million
St. Louis Science Center, St. Louis, MO - 1.02 million
Smithsonian's Steven F. Udvar-Hazy Center, Chantilly, VA - 1 million

America's Most Popular Museums | ForbesTraveler.com